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The Centers for Disease Control and Prevention (CDC) has outlined antibiotic treatment protocols for outpatient and inpatient treatment of PID. These are summarised below for ease of reference for healthcare professionals.
The CDC lists two currently recommended intravenous and oral or intramuscular and oral treatment protocols, labeled as A and B. The intramuscular and oral regimens are detailed below since it is more convenient and cost effective for outpatient use in most African clinical situations.
For inpatient treatment of PID, the CDC also lists 2 currently accepted treatment regimens, again labeled as A and B.
This regimen is continued for 24 hours after the patient remains clinically improved, after which doxycycline 100 mg is given orally twice daily for a total of 14 days. If a TOA is present, clindamycin or metronidazole is used with doxycycline for more effective anaerobic coverage.
IV therapy may be discontinued 24 hours after the patient improves clinically, and oral therapy with 100 mg doxycycline twice daily should be continued for a total of 14 days. If tubo-ovarian abscess (TOA) is present, clindamycin or metronidazole may be used with doxycycline for more effective anaerobic coverage.
An alternative parenteral regimen is ampicillin-sulbactam 3 g IV every 6 hours in conjunction with doxycycline 100 mg orally or IV every 12 hours.
CDC: Pelvic Inflammatory Disease: Treatment Guidelines. 2021. Retrieved March 10, 2023.
Published: March 5, 2023
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