Why African Girls Need the HPV Vaccine

By Chika Jones RN RM RPHN BNSC Freelance Health Writer. Medically reviewed by the DLHA Team.

 

A nurse drawing HPV vaccine from a vial into a syringe for a vvaccination

  A black nurse withdrawing vaccine from a vial into a syringe. Image source: Freepik

 

Highlights 

  • Human Papillomavirus is the primary cause of cervical cancer.
  • HPV vaccination can prevent up to 90% of cervical cancer cases
  • WHO recommends adolescent girls to receive HPV vaccination aged 9-14 years.
  • Awareness campaigns, community outreaches, and school-based vaccination programs can improve vaccine uptake

 

Introduction 

Human Papillomavirus (HPV) is the main cause of cervical cancer. HPV has over 100 subtypes. Low-risk HPV (HPV 6 and 11) causes genital warts, while high-risk HPV (HPV 16 and 18) causes cervical cancer [1]. Cervical cancer affects women irrespective of background, race, and economic status. Cervical cancer is a major health threat affecting sub-Saharan Africa women. HPV vaccination is crucial for African girls to prevent cervical cancer and promote health.

This article explores the importance of HPV vaccination for African girls, factors influencing vaccine uptake, and strategies to promote vaccination in Africa.

The Human Papillomavirus

  A picture explaining Human Papillomavirus. Click on image to enlarge. Image source: Freepik

 

Understanding the Link between HPV and Cervical Cancer 

HPV is transmitted through sexual contact. Most HPV infections resolve on their own within two years without noticeable symptoms. However, persistent infections with high-risk HPV types such as HPV 16 and 18 can lead to abnormal cell growth in the cervix. If left untreated, these abnormal cells can develop into cancer and potentially spread to other parts of the body [2].

HPV is associated with a range of health issues beyond cervical cancer including:

  • Genital warts are caused by low-risk HPV. Warts can occur in the mouth, throat, or anal region. Respiratory papillomatosis is rare but occurs if warts develop on the throat [1].
  •  Over 90% of anal and cervical cancers.
  •  Nearly 70% of vaginal cancers.
  •  Over 60% of penile cancers [3].

 

Types of HPV Vaccine

WHO licensed six HPV vaccines to be used globally. They are shown in table 1 below.

Types of HPV vaccine

Table 1. Detailing available HPV vaccines. Click on image to enlarge. Source.

 

Cervarix, Gardasil, and Gardasil-9 are currently available in  sub-Saharan Africa.  Cervarix protects against two HPV types that cause cancer. Gardasil protects against four HPV types that cause cancer and genital warts. Gardasil 9 protects against nine HPV types, covering both cancer-causing and wart-causing strains.

There are 12 high-risk types of HPV 31, 33, 45, 52, and 58. These types could also cause cervical cancer but HPV 16 and 18 are more likely to cause HPV-related cancers [1].

The HPV vaccine triggers production of antibodies that recognize and destroy HPV. This prevents HPV from entering cells [3].

A young African girl getting HPV vaccine

 An image of a girl receiving vaccination Image source: Freepik

 

Benefits of HPV Vaccination for African Girls

  • Cervical cancer is a preventable disease. HPV vaccines is a primary prevention measure against cervical cancer [4]
  • HPV vaccination can prevent HPV related diseases like genital warts and HPV related cancer
  • The HPV vaccination provides long lasting defence against diseases caused by HPV. HPV vaccines can protect up to 90% of cervical cancer cases and up to 11 years of protection from a single dose. This observation is noted in bivalent and quadrivalent vaccines
  •  HPV vaccines reduce the death rate from cervical cancer and HPV-related diseases among African girls and women. HPV vaccines, widely used, could prevent 85% of cervical cancer cases
  • Cervical cancer and HPV-related diseases could also constitute high costs to the healthcare system. HPV vaccination reduces healthcare costs related to the treatment and management of cervical cancer and HPV-related diseases.

 

When Should African Girls Get the HPV Vaccine? 

African women who engage in sexual activity may contract HPV unknowingly, and the HPV vaccine may not treat it. Hence, WHO recommends the HPV vaccine for adolescent girls aged 9-14 before they engage in sexual activity.

The World Health Organization (WHO) has updated its HPV vaccination recommendations as shown in Table 2 below:

WHO recommended HPV vaccination schedule

Table 2: WHO recommended HPV vaccination schedule. Click on image to enlarge. Source: WHO. 2022

 

Challenges and Solutions for HPV Vaccination in Africa

HPV vaccines are available in Africa but it is not being fully implemented. Findings reveal that HPV vaccination coverage in sub-Saharan Africa is 20%. Let us discuss the challenges of HPV vaccination and possible solutions.

  • Most African girls, parents or mothers may not be aware that HPV vaccination is available   

Solution: Awareness campaigns must be held in schools to educate African girls on HPV vaccination.  Research shows that individuals with knowledge about HPV vaccination increased their compliance.

Community outreaches must be done to educate African women and mothers about HPV vaccination for themselves, their sisters, and their daughters. Mass media exposure on the radio, television, and the internet must be done to sensitize the public about HPV vaccination.

 

  • African culture is rooted in abstinence, purity, and waiting till marriage.

African mothers may not be worried about cervical cancer and its related diseases and they could believe that their daughter would wait and there's no need for her to take the vaccination.    

Solution: Healthcare professionals should counsel mothers to let their daughters receive the HPV vaccine as it protects them from future harm.

 

  • HPV vaccines require proper infrastructure, a cold storage room, cold delivery chain, and trained healthcare professionals.

These conditions may not readily be available in some African countries, leading to poor uptake of HPV vaccination.

Solution: The structural challenges must be identified and resolved to improve African girls' safe uptake of HPV vaccination.

 

  • Some African parents may have misinformation on HPV vaccination.

They may have beliefs that the vaccination would make their daughters more promiscuous or they may be worried about potential side effects.   

Solution: Community outreaches should be engaged respecting community culture and beliefs to dispel myths or misconceptions about HPV vaccination.

 

  • Although HPV vaccination is free in most African countries, other socioeconomic considerations may constrain African parents from taking their daughters to the hospital to receive the vaccination.            

Solution: School-based HPV vaccination could be implemented to ensure every African girl receives it with parental consent. Healthcare facilities should be readily available and accessible in African rural areas.

 

Conclusion 

Cervical cancer is an eminently preventable disease through HPV vaccination. Most African women may have cervical cancer and not even know until it’s too late for a good treatment outcome. For this reason and more, it is very essential for every African girl and woman to be vaccinated for HPV. While factors such as lack of awareness, misinformation and socioeconomic status conditions could affect HPV vaccination uptake among African girls, addressing cultural and infrastructural challenges, and implementing effective communication strategies, can help lower parental resistance for African girls to be vaccinated against HPV. 

 

References 

1. National Cancer Institute. HPV and Cancer [Internet]. Updated 2025 May 9. [Cited July 31, 2025]. Available from here.  

2. National Cancer Institute. Cervical Cancer [Internet]. Updated 2024 June 15. [Cited July 31, 2025]. Available from here

3. Akhatova A, Azizan A, Atageldiyeva K, Ashimkhanova A, Marat A, Iztleuov Y, et al. Prophylactic Human Papillomavirus Vaccination: From the Origin to the Current State. Vaccines. doi: 10.3390/vaccines10111912. 2022;10(11):1912. Available from here

‌4. Kutz JM, Rausche P, Tarik Gheit, Dewi Ismajani Puradiredja, Fusco D. Barriers and Facilitators of HPV Vaccination in Sub-Saharan Africa: A Systematic Review. BMC Public Health. 2023;23(974). doi:  10.1186/s12889-023-15842-1. Available from here. ‌
 

 

Related:

Cervical Cancer: What African Women Need to Know

Cervical Cancer Screening Information for African women


 

Published: August 23, 2025

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